“This innovative approach and effective method for local siRNA delivery could have wide applications including diabetic wound healing, a significant and growing problem across the globe,” said Christine Kelley, Ph.D., division director in the National Institute of Biomedical Imaging and Bioengineering, part of the NIH. The study was supported by National Institutes of Health (NIH) grants EB021750 and AR056138. 16 by the journal Advanced Materials, the researchers demonstrate they did this in a mouse model by “packaging” the siRNA in protective nanoparticles and embedding the particles in a porous polyester urethane scaffold. One of the biggest challenges is delivery - getting siRNA into the cell. Small interfering ribonucleic acids (siRNAs) can block translation of messenger RNA into proteins, including enzymes that regulate the activity of transcription factors, as was done in this work. health care system more than $25 billion a year, according to one estimate. If further animal studies confirm the initial findings, the drug-containing scaffold could provide a new approach to healing chronic wounds, which afflict millions of patients with diabetes and other diseases and cost the U.S. (photo by Susan Urmy)īiomedical and chemical engineers at Vanderbilt University, working with a pathologist, have constructed a sponge-like, biodegradable tissue “scaffold” that releases an enzyme-blocking molecule to indirectly activate endogenous pathways and enhance tissue regeneration and wound healing. From left, Scott Guelcher, Ph.D., Jeffrey Davidson, Ph.D., Christopher Nelson and Craig Duvall, Ph.D., showed that an enzyme-blocking molecule released by a biodegradable scaffold can enhance wound healing in a mouse model.
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